RNA editing

In recent years, the field of cancer research has witnessed a growing interest in targeting RNA editing as a potential therapeutic strategy. Adenosine Deaminase Acting on RNA (ADAR), a key enzyme involved in RNA editing, has emerged as an attractive target for cancer therapy. In this blog post, we will explore the role of ADAR and RNA editing in cancer and the potential of ADAR inhibitors as effective cancer therapeutics, highlighting the progress made in this area and the challenges that lie ahead.

DNA damage is a phenomenon that can be detrimental to genomic integrity. Thankfully, our bodies have adapted many pathways to repair such DNA damage to prevent mutagenesis and cell death. There are many different topics related to DNA damage and repair, and I have recently focused on two other interesting topics related to this. In my first blog, I touched on the epigenetic role of DNA damage.

by SeHee Park

by SeHee Park

In humans, Adenosine (A) to Inosine (I) conversion within RNA is mediated by deaminase enzymes known as ADARs (Adenosine deaminases acting on dsRNA). This change in RNA component by ADARs has numerous effects on biological pathways as discussed in my previous blog, "How Does RNA Editing Affect Human Health?".

by SeHee Park