Howard Hughes Medical Institute Integrating Medicine in Basic Science (HHMI-IMBS)
In partnership with colleagues in the School of Medicine, the Biotechnology Program administered the Howard Hughes Medical Institute Integrating Medicine in Basic Science (HHMI-IMBS) translational research program from 2006 - 2014 (HHMI Med-Into-Grad Initiative Grant 56006769, PI Prof. Fred Meyers). The UC Davis HHMI IMBS program introduced PhD students in biomedical research and engineering to the world of clinical medicine, with the goal of preparing them for careers in clinical academic or industrial biopharma settings. Over the course of the award period, this novel training program brought 65 fellows into clinical settings early in their training to promote innovative "bench to bedside" problem-solving approaches and the development of new biotech therapeutics, diagnostics and related technologies for human health.
Biotech Program Director, Dr. Judy Kjelstrom, served on the program implementation team as chair of recruitment and retention and played a key role in mentoring trainees throughout the eight years of the award period. Program leaders, Dr. Ann C. Bonham, Dr. John A. Robbins and Dr. Anne A. Knowlton, developed the one-year, multifaceted curriculum, which included diverse clinical experiences and rotations, as well as interactive training and courses with medical students, basic scientists, clinician scientists and clinician-educators. The program used cardiovascular disease (broadly defined to include obesity, diabetes, heart failure, stroke, etc.) and oncology/cancer biology as models for integrating medical principles and clinical approaches to patient care into the trainees' basic research programs. Key training elements included clinical immersion with didactics, journal clubs, and special projects.
Along with the NIH BTP, this program helped to lay the foundation for expanded graduate training efforts in human health at UC Davis. Dr. Judy Kjelstrom, Biotechnology Program director emerita, served as a member of the campus team that developed and was awarded the initial NIH Broadening Experiences in Scientific Training (BEST) funding in 2013. The NIH BEST award allowed the campus to establish the Frontiers of University Training to Unlock the Research Enterprise (FUTURE) program, which is currently supported by the UC Davis Clinical and Translational Science Center and the School of Medicine.
Program-Related Media and Resources
- "Training the Translational Research Teams of the Future: UC Davis—HHMI Integrating Medicine into Basic Science Program" by Anne A. Knowlton, MD, et. al. UCDavis_HHMI_IMBS_2013.pdf
- "Grants Push Grad Schools to Bring Research and Medicine Together" by Jim Keeley (November 17, 2009)
Trainees (2013 - 2014)
- Julie Beegle (Comparative Pathology, PI Jan Nolta)
- Pearl Chen (Molecular, Cellular and Integrative Physiology, PI Nipavan Chiamvimonvat)
- Patrick Falahee (Immunology, PI Scott Simon)
- Jinzhen Fan (Biomedical Engineering, PI Tingrui Pan)
- Tingting Liu (Molecular, Cellular and Integrative Physiology, PI Anne Knowlton)
- Justin Madrigal (Biomedical Engineering, PI Eduardo Silva)
- Christian Siltanen (Biomedical Engineering, PI Alexander Revzin)
- Anna Marie Tuazon (Biochemistry, Molecular, Cellular and Developmental Biology, PI Luis Carbajal-Carmona)
Trainees (2012 - 2013)
- Calvin Balatbat (Biochemistry, Molecular, Cellular and Developmental Biology, PI Jan Nolta)
- Steven Behrens (Biomedical Engineering, PI Colleen Clancy)
- Bert Frederich (Molecular, Cellular and Integrative Physiology, PI Nipavan Chiamvimonvat)
- Hyun Tae Hwang (Pharmacology and Toxicology, PI Anne Knowlton)
- Justin Klein (Biomedical Engineering, PI Simon Cherry)
- Angela Monterrubio (Biochemistry, Molecular, Cellular and Developmental Biology, PI Sheila David)
- Mikella Robinson (Molecular, Cellular and Integrative Physiology, PI Chao-Yin Chen)
- Angela Papalamprou (Molecular, Cellular and Integrative Physiology, PI Leigh Griffiths)
Trainees (2011 - 2012)
- Samuel Chung (Pharmacology and Toxicology, PI Tzipora Goldkorn)
- Nicole DeJesus (Biomedical Engineering, PI Crystal M. Ripplinger)
- Pasha Hadidi (Biomedical Engineering, PI Kyriacos Athanasiou)
- Anthony Herren (Molecular, Cellular and Integrative Physiology, PI Donald Bers)
- Alan Lombard (Biochemistry, Molecular, Cellular and Developmental Biology, PI Maria Mudryj)
- Elizabeth Martin (Molecular, Cellular and Integrative Physiology, PI Helen Raybould)
- Dipali Patel (Biomedical Engineering, PI Alexander Revzin)
- Benjamin Yuen (Molecular, Cellular and Integrative Physiology, PI Paul Knoepfler)
Trainees (2010 - 2011)
- Shannon Chase (Biomedical Engineering, PI Scott Simon)
- Shannamar Dwey (Molecular, Cellular and Integrative Physiology, PI Aldrin Gomes)
- Elizabeth Doughty (Biomedical Engineering, PI Nesrin Sarigul)
- Dae Uy Kim (Biomedical Engineering, PI John Werner)
- Diana Lac (Pharmacology and Toxicology, PI Kit Lam)
- Alison Lee (Pharmacology and Toxicology, PI Anne Knowlton)
- JohnPatrick Rogers (Chemisry, PI Sheila David)
- Yannan Xi (Nutritional Biology, PI Fawaz Haj)
Trainees (2009 - 2010)
- Barbara Bailus (Genetics, PI David Segal)
- Yun Joon Jung (Biomedical Engineering, PI Jan Nolta)
- Alan Man (Biomedical Engineering, PI Peter Bannerman)
- Matthew Soicher (Biomedical Engineering, PI David Fyhrie)
- Crystal Tjhia (Biomedical Engineering, PI David Fyhrie)
- Ying Wang (Biomedical Engineering, PI Scott Simon)
- Maelene Wong (Biomedical Engineering, PI Leigh Griffiths)
- Melissa Zerofsky (Nutritional Biology, PI Charles Stephenson)
Trainees (2008 - 2009)
- Daniel Bricarello (Applied Science, PI Atul Parikh)
- Brett Fite (Biophysics, PI Laura Marcu)
- Darren Hwee (Molecular, Cellular and Integrative Physiology, PI Sue Bodine)
- Richard Myers (Molecular, Cellular and Integrative Physiology, PI Wenbin Deng)
- Thuc Nguyen (Biomedical Engineering, PI Soichiro Yamada)
- Emily Pfeiffer (Biomedical Engineering, PI Abdul Barakat)
- Erin Schwartz (Biochemistry and Molecular Biology, PI Wolf Heyer)
- Siwei Zhao (Biomedical Engineering, PI Tingrui Pan)
- Pavel Zimin (Pharmacology and Toxicology, PI Heike Wulff)
Trainees (2007 - 2008)
- Richard Carpenter (Chemical Engineering, PIs Mark Kurth and Kit Lam)
- Lisa Lit (Genetics, PI Frank Sharp)
- Jennifer Phipps (Biomedical Engineering, PI Laura Marcu)
- Stephanie Pulford (Mechanical and Aeronautical Engineering, PI Cristina Davis)
- Mary Saunders (Comparative Pathology, PIs Kit Lam and Ron Li)
- Padmini Sirish (Molecular, Cellular and Integrative Physiology, PI Nipavan Chiamvimonvat, MD)
- Brianna Wallace (Physiology, PI Martha O'Donnell)
- Tyler Weeks (ASE, PI Tom Huser)
Trainees (2006 - 2007)
- Kim Barnholt (Molecular, Cellular and Integrative Physiology, PI John C. Rutledge, MD)
- Astra Chang (Molecular, Cellular and Integrative Physiology, PI Nipavan Chiamvimonvat, MD)
- Rachel DeVay (Biochemistry and Molecular Biology, PI Jodi Nunnari)
- Edward A. Ganio (Genetics, PI Nobuko Hagiwara)
- Robert Michael Gower (Biomedical Engineering, PI Scott I. Simon)
- Caroline Meloty-Kapella (Cell and Developmental Biology, PI Richard P. Tucker)
- Zane Starkewolfe (Chemistry, PI Angelique Louie)
- Cindy Hsing-Ju Tsai (Pharmacology and Toxicology, PI Bruce Hammock)
